• Profile
Close

800 dietary supplements contained unapproved drug ingredients: FDA

IANS Oct 16, 2018

Nearly 800 dietary supplements sold over the counter from 2007 through 2016 contained unapproved drug ingredients, a new analysis of US Food and Drug Administration (FDA) data found.
 



 

 

 

 

 

 

 

Pieter A. Cohen, Associate Professor at the Harvard University, said that FDA discovered 746 adulterated supplements. More than one unapproved pharmaceutical ingredient was found in 20 per cent of those supplements. The presence of prescription medicines, often at unknown concentrations, means these supplements are essentially "unapproved drugs" that could be harmful to users' health, according to researchers.

"These products have the potential to cause severe adverse health effects owing to accidental misuse, overuse, or interaction with other medications, underlying health conditions, or other drugs within the same dietary supplement," researchers led by Madhur Kumar of the California Department of Public Health Food and Drug Branch, was quoted as saying by CNN.

For the study, published in the journal JAMA Network Open, Kumar and his co-authors reviewed the FDA's Tainted Products Marketed as Dietary Supplements-CDER database for 2007 through 2016. Most of the adulterated products, about 45 per cent, were marketed for sexual enhancement, weight loss (about 41 per cent) or muscle-building (12 per cent). 

Drugs found in sexual enhancement products included sildenafil, tadalafil and vardenafil, all active ingredients in prescription medications intended for erectile dysfunction, which, when overused, can cause serious damage to the blood vessels.

The most common pharmaceutical ingredients detected in adulterated weight loss products were sibutramine, which was removed from the US market in 2010 due to cardiovascular risks, and the laxative phenolphthalein. Many of the adulterated muscle building products contained undeclared anabolic steroids, which, when abused, can lead to mental problems in the short term and kidney problems, liver damage and heart problems in the long term.

Other drugs found in the adulterated supplements include antidepressants and antihistamines, both of which may have side effects and interact with other medications. "Only 360 of 746 (48 per cent) were recalled, leaving the majority of adulterated supplements, more than 350 products, available for sale," Cohen said. Thus, according to Cohen, "more than FDA action will be required to ensure that all adulterated supplements are effectively and swiftly removed from the market."

Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay