Takahashi S, Sanjo N, Miyamoto S, et al. - In order to assess the progression of chronic progressive neuro-Behçet's disease (CPNBD) during treatment, researchers performed a retrospective, longitudinal comparative analysis of the clinical features and brain MRI in patients with CPNBD. Participants were classified into three groups: NBD with acute encephalomeningitis alone (Group A, 8 patients with acute neuro-Behçet's disease), primary progressive CPNBD (Group B, 3 patients), and a combination of acute encephalomeningitis, and chronic progression (Group C, 2 patients). Routine laboratory tests and the monthly rate of enlargement of the width of the third ventricle (ΔWTVm) and relative value of ΔWTVm to the transverse cerebral diameter (ΔWTVIm) have been statistically assessed. Effective treatment for CPNBD tended to minimize ΔWTVm and ΔWTVIm in some patients. A highly sensitive candidate biomarker of early diagnosis and treatment efficacy is the sequential assessment of WTV in patients with CPNBD.