Rizk MM, et al. – This research evaluated the proposition that attention control as determined by Stroop task interference was based on white matter integrity in fronto–cingulate regions. This correlation was gauged via diffusion tensor imaging (DTI) in major depressive disorder (MDD) and healthy volunteers (HV). It was noted that the structural connectivity of white matter network of caudal anterior cingulate cortex (cACC) was associated with magnitude of Stroop interference in HVs, but not MDD. The cACC–frontal network, sub–serving attention control, could be disrupted in MDD. Less cognitive control could encompass the enhanced effects of salience in HVs, or less effective response inhibition in MDD. Advanced studies on salience and inhibition components of executive function could aid in comprehending the link between brain white matter changes and executive dysfunction in MDD.