Siddiqi A, Abdo ZE, Rossman SR, et al. - Researchers conducted a thorough review of the current literature on the various forms of irrigations and their additives used in the treatment of acute and chronic periprosthetic joint infections (PJIs) with the aim to determine the efficacy and limitations of each irrigation solution as pertaining to pathogen eradication in the treatment of PJI. Following were the antiseptic solutions included in the identified works: povidone-iodine, chlorhexidine gluconate, acetic acid, hydrogen peroxide, sodium hypochlorite, hypochlorous acid, and preformulated commercially available combination solutions. Findings from the literature review suggest a possible role of intraoperative use of antiseptic irrigants in treating prosthetic joint infection, however, there is a lack of definitive clinical studies comparing antiseptic to no antiseptic irrigation. In addition, there are no clinical head-to-head comparisons of different antiseptic irrigants describing an optimal irrigation solution.