Silva D, et al. - In this double-blinded cross-over trial, researchers examined how Mediterranean (MdM) vs fast food (FFM) meals influence exercise-induced adipokines changes. A total of 46 participants were randomized to one of two standardized iso-energy pre-exercise meals (FFM or MdM-type); 39 participants completed the trial. Circulatory levels of adipsin, resistin, lipocalin and PAI-1, but not adiponectin, increased following acute exercise. The increase of adipsin after the exercise test was potentiated when a pre-exercise Mediterranean meal was provided, which possibly relates to the immune regulatory role of adipsin. Findings, thereby, suggested a cross-talk between the immune and metabolic immediate response to exercise. This effect is modulated by the pre-exercise diet composition, according to study results.