Chiou JH, et al. - Herein, researchers contemplated the complex inter-connection between frailty and pain, and the mediating roles of cognitive function, morbidity and mood in this nexus. Findings illustrated that moderate pain correlated with frailty in those older than 65 years, but not younger ones among cognitively and functionally sound community-dwelling adults aged ≥50 years. It was determined that pain exerted a direct impact on frailty. Moreover, depression partially mediated the pain–frailty nexus.