Jensen BW, Watson C, Geifman N, et al. - Higher risks for obesity-related cancer (ORC)(in men) and higher all-cause mortality (both genders) were observed in patients who lost weight after type 2 diabetes (T2D) diagnosis vs those with stable obesity.

• In this study including 7,708 patients with T2D, latent class trajectory modelling of body mass index (BMI) was used to assess if weight loss after T2D diagnosis impacted cancer incidence and all-cause death.

• Four gender-specific BMI classes were defined; stable-overweight, stable-obese, obese-slightly-decreasing, and obese-steeply-decreasing; including 41%, 45%, 13%, and 1% of women, and 45%, 37%, 17%, and 1% of men, respectively.

• In women, similar ORC risks were noted in the stable-obese class and obese-slightly-decreasing class, whereas lower risks were present in the stable-overweight class.

• Among men, higher risks of ORC (hazard ratio, HR = 1.86) were observed in the obese-slightly-decreasing class vs the stable-obese class, while the stable-overweight class showed similar risks.

• No links were found for non-ORC.

• Increased mortality was experienced by women (HR = 1.60) and men (HR = 2.37) in the obese-slightly-decreasing class vs the stable-obese class.