Dankbaar JW, et al. - Researchers attempted to study clinical and multimodality CT imaging characteristics on admission in patients with wake-up stroke (WUS) vs patients experiencing a stroke with a known onset time. From a large prospective cohort study (Dutch acute stroke study), all patients were selected. They discovered that the differences in clinical and imaging characteristics between WUS patients vs patients who arrive at the hospital within the time criteria for intravenous or endovascular treatment were minor. This suggests that CT imaging could help identify WUS patients who could benefit from treatment and rule out those with severe ischemia and poor collaterals.