Danielsson O, Nissinen MJ, Jula A, et al. - Waist circumference (WC) and hip circumference (HC) have independent and joint correlations with liver disease, which are mostly expressed by the waist-hip ratio (WHR). These anthropometric measurements are influenced by both body fat distribution and muscle mass.

• Individuals from the Health 2000 and FINRISK 1992-2012 studies were included in the cross-sectional study (n = 6,619) and the longitudinal cohort (n = 4,092,3).

• WC and HC were found to have independent and inverse relationships with both liver enzymes and incident liver disease in both men and women.

• HC altered the relationships between WC and liver enzymes, as well as between WC and incident liver disease, notably in men.

• Liver enzymes and the risk of the liver disease rose with rising WC, more so in those with high WHR than in people with low WHR.

• WHR was largely mirrored by WC and HC in terms of body fat distribution and muscle mass.