Al-Shaikh FSH, Duara R, Crook JE, et al. - This cross-sectional study was conducted to investigate the major source of cholinergic innervation, the nucleus basalis of Meynert (nbM), in order to ascertain whether there is differential involvement of NFT accumulation or neuronal loss among Alzheimer disease (AD) subtypes. Researchers examined 1,361 AD subtypes and 103 nondemented controls. They further investigated demographic and clinical characteristics, including cognitive decline measured utilizing the Mini-Mental State Examination score. For neuronal loss and NFT accumulation, the anterior nbM was examined quantitatively. These findings give supportive evidence that NFT accumulation in the nbM may underlie more widespread and severe cholinergic deficits in young-onset AD, particularly in individuals with HpSp AD. Furthermore, these findings underscore the significance of considering the age at onset, gender, and apolipoprotein E genotype during evaluating results in AD.