Im JP, et al. - The intention of experts was to scrutinize the correlation between visceral obesity and the incidence and recurrence of colorectal adenoma. Findings illustrated that a higher visceral adipose tissue (VAT) area was dose-dependently related to a higher risk of incident adenoma. It was also determined that increases in body mass index (BMI) and waist circumference (WC) as a surrogate marker of abdominal obesity exhibited a connection with a higher risk of recurrent adenoma.

Methods

• An analysis was conducted of 2,244 participants between 2006 and 2007.
• Follow-up of the candidates was performed until 2014 according to the initial colonoscopic and histopathologic findings.
• During this research, incident and recurrent colorectal adenoma groups were defined as individuals with a positive follow-up colonoscopy from among the normal and adenoma groups, respectively, at the baseline colonoscopy.

Results

• Out of 1,163 subjects (51.8%) who received a follow-up colonoscopy, 509 enrollees (43.8%) and 654 subjects (56.2%) were allocated into the normal and adenoma cohorts.
• The occurrence of colorectal adenomas was noted in 592 individuals (50.9%) during median period of 43 months, with an incident adenoma prevalence of 39.1% and a recurrent adenoma prevalence of 60.1%.
• A connection was discovered between an increase in visceral adipose tissue (VAT) area with a higher incidence of adenoma (highest quintile vs lowest quintile of the VAT hazard ratios [HRs], 2.16; 95% confidence interval [CI], 1.26-3.71; HR, 1.32 [per 1-SD]; 95% CI, 1.10-1.60) in the multivariable analysis.
• Findings illustrated that increases in body mass index (BMI) and waist circumference (WC) were related to recurrent adenoma (HR 1.33 [per 1 kg/m²], 95% CI, 1.18-1.46; HR, 1.04 [per 1 cm], 95% CI, 1.01-1.07, respectively) in the multivariate analysis.