Pan Y, et al. - Interviewing 1227 people with HIV infection from 11 hospitals in the US, the CTN0049 study, Project HOPE (Hospital Visit as Opportunity for Prevention and Engagement for HIV-infected Drug Users) determined the eligibility for participation in a randomized trial. Using these screening interviews, researchers examined groups that are at highest risk for having a detectable viral load (VL) and engaging in HIV transmission behaviors via conducting a cross-sectional study with multivariable analysis. Viral suppression was reported in 42.8%. A detectable VL was noted among persons who were more likely to have sex partners who were HIV-negative or of unknown status, report not cleaning needles after injecting drugs, and to engage in sex acts while high on drugs or alcohol compared to their counterparts. Unsuppressed HIV infection was reported in many hospitalized people; these people were more likely to engage in HIV transmission behaviors than those with viral suppression. For preventing HIV transmission, they recommend developing behavioral interventions targeting HIV transmission behaviors toward patients with unsuppressed HIV VLs in the hospital setting.