Vila-Rodriguez F, et al. - Experts aspired to determine whether APOE-ε4 status had a pleiotropic effect in early stages of the illness. In this study, they reported improvement in verbal memory in persons afflicted by first-episode psychosis (FEP) who were APOE-ε4 carriers and replicated the prominent verbal memory deficits present in FEP. This work gave additional evidence leading to an antagonistic pleiotropic effect of APOE-ε4 in neuropsychiatric disorders. The outcomes merited further research into antagonistic pleiotropic effects in schizophrenia.