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Ventricular tachycardia, premature ventricular contractions, and mortality in unselected patients with lung, colon, or pancreatic cancer: A prospective study

European Journal of Heart Failure Dec 08, 2020

Anker MS, von Haehling S, Coats AJS, et al. - Researchers compared 120 prospectively enrolled unselected patients with lung, colon, or pancreatic cancer vs 43 healthy controls comparable in age and sex distribution to determine the prevalence of ventricular arrhythmia in cancer patients, as well as its as well as prognostic significance. They included 33 patients with colorectal cancer, 54 with pancreatic cancer, and 33 with non‐small cell lung cancer, all without manifest cardiovascular disease. In cancer patients vs controls, there was no increase in the number of premature ventricular contractions (PVCs) over 24 hours. Non‐sustained ventricular tachycardia (NSVT) was detected more often in cancer patients vs. controls (8% vs. 0%). Independent of other univariable mortality predictors, both NSVT and PVCs were significant predictors of mortality, as seen in the multivariable analysis. This increases the prospect of cardiovascular death being a target for future management interventions in selected malignancies.

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