Pinho DF, et al. - A retrospective study was conducted to explore the prognostic value of quantitative metabolic parameters from pretreatment PET/CT scans of patients with squamous cell cervical cancer. The study population consisted of 120 individuals with biopsy-proven squamous cell carcinoma of the cervix who underwent FDG PET/CT for initial tumor staging. They obtained primary tumor maximum standardized uptake value (SUV_max) and mean standardized uptake value (SUV_mean), tumor glycolytic activity, metabolic tumor volume (MTV), and metabolic intratumoral heterogeneity index (calculated as the AUC for the cumulative standardized uptake value [SUV]–volume histogram [CSH] index). In individuals with cervical cancer, tumor heterogeneity on pretreatment PET/CT is correlated with OS and PFS. There was a significant association between MTV and OS.