Boccalatte LA, Higuera F, Gómez NL, et al. - In this systematic review of 16 studies, researchers analyzed accessible proof to determine positive predictive value, negative predictive value, sensitivity, and specificity in clinical cases where ¹⁸F-fluorocholine positron emission tomography–computed tomography (PET/CT) could be useful as a method for locating lesions, as well as the benefits and controversial aspects of the method. Participants in the study were 619 patients. Investigators discovered that ¹⁸F-fluorocholine PET/CT has high sensitivity, specificity, positive predictive value, and diagnostic precision vs first-line tests, where concomitant thyroid disease or ectopic glands may reduce such indices. It is a second-line test when there are adverse or discordant outcomes of ultrasonography and sestamibi scans. Findings suggested that ¹⁸F-fluorocholine PET/CT may be helpful if hyperplasia, multiple lesions, persistent or recurrent hyperparathyroidism, small or ectopic adenomas, or normalcalcemic hyperparathyroidism are suspected.