O'Connell B, et al. - In accord with PRISMA guidelines, researchers performed this systematic review to determine the positive and negative predictive value of blood biomarkers for concussion; describing the clinical and biological contexts that help assess the use of these markers in sport-related traumatic brain injuries (TBIs). Of 4352 identified publications, 26 articles were included in the review. S100B, tau, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), were examined. Findings point to only a limited role of blood biomarkers in the evaluation and management of concussion, presently. As a diagnostic biomarker, the most promising clinical utility was shown by S100B. To further enhance the diagnostic accuracy, the use of blood biomarkers, in combination with other clinical data, such as head computed tomography, was suggested.