Butler SS, et al. - Using the novel Surveillance, Epidemiology, and End Results Active Surveillance/Watchful Waiting database, researchers examined 52,940 men with intermediate-risk prostate cancer (PCa) in the US to describe use of active surveillance (AS) and early death outcomes in these subjects. The participants were actively managed (AS, radiotherapy, or radical prostatectomy) from 2010 through 2015. They reported an increasing use of AS for patients with intermediate-risk PCa in the US over this time period (3.7% to 7.3%); this is true especially for older men and patients with favorable intermediate-risk disease. With AS, low early estimates of cancer-specific and overall death rates were reported, though they are significantly higher compared with treatment. Favorable risk disease; black race; higher socioeconomic status; older age; and diagnosis in the West, Northwest, or Midwest regions of the US were linked with AS.