Hasin DS, Shmulewitz D, Cerdá M, et al. - Considering a possible risk for nonmedical cannabis use and cannabis use disorder among individuals with pain in relation to changes in US marijuana laws, attitudes, and use patterns, researchers here investigated US adults with and without pain for disparities in the prevalence of nonmedical cannabis use and cannabis use disorder, as well as to assess if these differences widened over time. They used logistic regression to analyze data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, 2001–2002; N = 43,093) and NESARC-III (2012–2013; N = 36,309). Respondents with vs without pain exhibited a higher prevalence of any nonmedical cannabis use (2001–2002: 5.15% compared with 3.74%; 2012–2013: 12.42% compared with 9.02%) and of cannabis use disorder (2001–2002: 1.77% compared with 1.35%; 2012–2013: 4.18% compared with 2.74%). Adults with pain are thus suggested to be a group frequently vulnerable to adverse cannabis use outcomes, warranting clinical and public health attention to this risk. They recommend psychiatrists and other health care providers treating patients with pain to monitor such cases for signs and symptoms of cannabis use disorder.