Martin-Lorenzo M, et al. - Given that spironolactone appears the most effective choice to treat resistant hypertension once triple therapy including a diuretic fails, researchers investigated urinary proteome changes with potential capacity to predict response to spironolactone. They conducted a prospective study that included 29 individuals with resistant hypertension. They classified patients as responders or non-responders based on blood pressure control, and collected basal urine before spironolactone administration. Significant variations were observed in haptoglobin and haptoglobin-related protein among 3,310 identified proteins, with increased levels in non-responders vs responders before drug administration. Overall, this study for the first time established the predictive value of protein changes in basal urine for patients’ response to spironolactone.