Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria
Cardiovascular Diabetology Apr 12, 2018
Currie GE, et al. - Researchers investigated if the urinary proteomic classifier CKD273 is a determinant of mortality and cardiovascular disease in patients with microalbuminuria (MA). They noted a correlation of CKD273 with urine albumin excretion rate (UAER), age, coronary artery calcium (CAC) score, N-terminal pro-brain natriuretic peptide (NT-proBNP) and estimated glomerular filtration rate (eGFR). As per observations, a multidimensional biomarker can provide information on outcomes associated with its primary diagnostic purpose. The urinary proteomic classifier CKD273 was shown to be associated with mortality in individuals with type 2 diabetes and MA even when adjusted for other established cardiovascular and renal biomarkers.
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