Szeto CC, et al. - Researchers investigated urinary micro-RNA (miRNA) targets for the diagnosis of IgA nephropathy (IgAN), using a development cohort and a validation cohort comprising 22 patients with IgAN and 11 healthy controls (CTL) and 33 IgAN patients and 9 healthy controls, respectively. They performed complete miRNA profiling of urinary sediment and quantified potential miRNA targets in the development cohort and validation cohort, respectively. According to findings, IgAN and healthy controls exhibited remarkably different urinary miR-150, miR-204, miR-431 and miR-555 levels. The best diagnostic accuracy was demonstrated by urinary miR-204 level alone, with area-under-curve of the receiver operating characteristic (ROC) curve 0.976. Urinary miR-204 yielded sensitivity and specificity of 100 and 55.5%, respectively, for diagnosing IgAN, at the cut-off 1.70 unit.