Yepes‐Calderón M, Sotomayor CG, Pena M, et al. - Researchers here examined whether urinary liver‐type fatty acid‐binding protein (uL‐FABP), a biomarker of kidney hypoxia and ischemia, is associated with graft failure in outpatient kidney transplant recipients (KTR) and whether it enhances risk prediction. In a cohort of 638 outpatient KTR with a functional graft ≥ 1‐year, 80 KTR developed graft failure during a median follow‐up of 5.3 years. uL‐FABP (median 2.11, interquartile range 0.93–7.37 µg/24"/>h) was noted to be prospectively linked with the risk of graft failure, independent of potential confounders including estimated glomerular filtration rate and proteinuria. For graft failure, uL‐FABP exhibited excellent differentiation ability (c‐statistic of 0.83); its addition to a prediction model composed by established clinical predictors of graft failure led to a significant improvement in the c‐statistic to 0.89.