Wang X, Karvonen-Gutierrez CA, Herman WH, et al. - Researchers assessed the relationships of urinary levels of arsenic, cadmium, mercury, and lead with longitudinal alterations in blood pressure in the Study of Women’s Health Across the Nation Multi-Pollutant Study. Participants were 1,317 White, Black, Chinese, and Japanese females, aged 45 to 56 years at baseline (1999–2000), whose systolic blood pressure (SBP) and diastolic blood pressure were recorded annually or biannually through 2017. At baseline, urinary metal concentrations were recorded. Greater annualized elevations in SBP and diastolic blood pressure were detected in women with higher concentrations of all four metals vs those with lower concentrations. Thus, acceleration of blood pressure increase in midlife women may result from exposure to heavy metals, this implies that continued efforts to attenuate these environmental exposures are required.