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Uric acid is not associated with diabetic nephropathy and other complications in type 1 diabetes

Nephrology Dialysis Transplantation Apr 17, 2018

Pilemann-Lyberg S, et al. - Using cross-sectional design, researchers assessed the link between plasma uric acid (UA) and the presence of diabetic complications including diabetic nephropathy and cardiovascular risk factors in Caucasian type 1 diabetes patients from the Steno Diabetes Center Copenhagen, by applying unadjusted and adjusted linear regression analyses and adjusting for sex, age, diabetes duration, body mass index, high-density lipoprotein cholesterol, smoking, haemoglobin A1c, 24-h pulse pressure, urinary albumin excretion rate (UAER), estimated glomerular filtration rate (eGFR) and treatment with renin–angiotensin–aldosterone system blockers. In type 1 diabetes patients, higher UA was shown to be related to lower kidney function and other diabetic complications. The link between higher UA and lower eGFR and lower diastolic blood pressure was found to be independent of traditional risk factors.
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