Ginestet F, et al. – This study aims to investigate regarding the value of upfront anti–H. pylori immunohistochemistry in this field. The interest of using immunohistochemistry as an upfront stain on gastric biopsies is still debated albeit being considered as a gold standard in the detection of H. pylori. Its use in the second line in case of ambiguous HE/Hematoxylin–Eosin Saffron (HES)–Giemsa result is more appropriate in authors opinion. To optimize the inexpensive but feasible HE/HES–based detection of H. pylori, further effort is needed.