Gao J, Gao L, Li Z, et al. - Researchers compared the perioperative and oncologic outcomes after pneumonectomy carried out by uniportal video-assisted thoracoscopic surgery (U-VATS) vs thoracotomy in cases with centrally located non–small cell lung cancer (NSCLC). They assessed patients with NSCLC who underwent pneumonectomy at the Shanghai Pulmonary Hospital (SPH) and Sun Yat-sen University Cancer Center (SYUCC) between 2011 and 2016. The SPH cohort comprised 579 patients, with 501 (86.5%) in the open group and 48 (13.5%) in the U-VATS group, and the SYUCC cohort included 271 patients, with 245 (90.4%) in the open group and 26 (9.6%) in the U-VATS group. As per outcomes, patients with central NSCLC can safely undergo pneumonectomy using U-VATS. Thoracoscopic surgery can be chosen by surgeons as a feasible choice. Without compromising the perioperative and oncologic outcomes, pneumonectomy can be performed by U-VATS compared with an open approach.