Weinstein M, et al. - In order to investigate the relationship between brain structure and/or activity and hand function, the authors examine the feasibility of using several modalities in this multiple case study: Electroencephalography (EEG), both structural and functional Magnetic Resonance Imaging (sMRI, fMRI), diffusion tensor imaging (DTI), transcranial magnetic stimulation (TMS), Electromyography (EMG) and hand function assessments. When studying upper-limb function in children with Cerebral Palsy (CP), the current outcomes reveal benefits from the use of different modalities; not least to accommodate the variations in tolerance and feasibility of implementation of the differing methods. These exposed multiple individual brain-reorganization patterns corresponding to different functional motor abilities. Further investigation is required to understand the transactional influences of early brain injury, neuroplasticity and developmental and environmental factors on hand function in order to develop targeted interventions.