Sangal NR, et al. - Experts sought to identify risk factors of unplanned reoperation after major operations of the head and neck. Pharyngectomy, followed by glossectomy, laryngectomy, and mandibulectomy was the operative procedure with the highest reoperation rate. The modification and adaptation of these risk factors to decrease the burden that unplanned reoperation places on patients, surgeons, and the health care system may be guided by the identification of a significant association of black race, disseminated cancer, total operation time, surgical site infection in either the superficial or deep spaces, wound dehiscence, or ventilator dependence for more than 48 hours after surgery with increased risk of reoperation in major head and neck surgery.