Louise-Eva V, Enaud R, Urien C, et al. - Researchers performed this study to examine the associations between indoor microbial exposures and pulmonary microbial communities as well as to report the role of microbial exposures on inflammatory as well as clinical results of patients suffering from severe asthma (SA). Enrollment of SA patients from the national COBRA cohort was done. Experts compared microbial communities from electrostatic dust collector and sputum samples of patients by type 2 (T2)-asthma endotypes, employing amplicon targeted metagenomics. Patients with T2-high SA vs those with T2-low SA demonstrated a rise in bacterial alpha-diversity and a reduction in fungal alpha-diversity of their indoor microbial floras, the latter was significantly related to fraction of exhaled nitric oxide concentrations. Overall, a potential link between the indoor mycobiome and clinical characteristics of SA patients was shown for the first time.