Kim JK, et al. - The growth rate of hepatocellular carcinoma (HCC) was determined by calculating the tumor volume doubling time (TVDT) and its effect on survival and recurrence to assess the clinical value of tumor growth rate in hepatocellular carcinoma (HCC) patients. An association was demonstrated between a fast HCC growth rate with poor liver function and aggressive tumor biology. HCC patients with shorter TVDTs showed poorer survival and recurrence outcomes as well as a poor response to TACE.