Bohlen M, et al. - Authors investigated 65 individuals to analyze the possible relationship between initial tumor volume and volume reduction following induction chemotherapy (ICT) and radiochemotherapy (RCT) with remission status, overall survival (OS) as well as disease-free survival (DFS) in locally advanced head and neck squamous cell carcinomas (LAHNSCC) cases. They did not find any association of primary tumor volume with complete remission rate, OS or DFS after ICT and RCT. They observed a significant impact on OS and DFS by the change in tumor volume between baseline imaging and post-RCT. They noted 72.14% was agreement between tumor volume and radiologic remission. They suggested that severe response to ICT did not predict a strong RCT result.