Roh JL, et al. - Researchers examined whether tumor-related leukocytosis (TRL) is valuable as a predictive biomarker for recurrence and survival after definitive surgery for oral cavity squamous cell carcinoma (OSCC). In this retrospective study of 322 patients who underwent tumor extirpation combined with neck dissection for treatment-naïve OSCC, they noted a significant association of TRL with advanced disease status, tumor size, invasion depth, poor differentiation, and T and N classifications, resulting in enhanced posttreatment recurrence rate, particularly in the distant site.