Yang Z, Feng J, Xiao L, et al. - This study was undertaken to determine if peptidoglycan recognition protein 2 (PGLYRP2), a pattern recognition receptor which is particularly expressed in liver and implicated in the regulation of innate immunity and immunosurveillance, is able to influence hepatocellular carcinoma (HCC) progression through regulating host antitumor immune responses. The study results showed that PGLYRP2 was down-regulated in HCC, which was associated with poor prognosis in individuals. PGLYRP2 overexpression in HCC cells significantly increased immune responses to antitumors in immune-competent mice and increased peripheral blood mononuclear cell immune response rates against HCC. According to findings, tumor-derived PGLYRP2 serves as a candidate biomarker for the serves immune response against HCC and improved patient results, suggesting the significance of hepatic PGLYRP2 in immunosurveillance of cancer and in the design of immunotherapy approaches.