Tricò D, et al. - Researchers tested whether triglycerides and very low-density lipoprotein (VLDL) were independently correlated with insulin secretion as well as whether the ethnicity/race modulates these associations. In a multiethnic cohort of 630 non-diabetic adolescents, fasting triglycerides and VLDL were measured. Results revealed that triglycerides and triglyceride-rich VLDL were correlated with both basal and glucose-stimulated insulin secretion, after adjustment for age, sex, ethnicity, BMI z-score, plasma glucose, and insulin sensitivity. They found that ethnicity per se did not modulate the effect of triglycerides/VLDL on insulin secretion but had an impact on lipid profile and β-cell function. It was noted that changes in triglyceride levels were proportional to changes in insulin secretion at follow-up and supported the hypothesis that hypertriglyceridemia was an important stimulus for β-cell insulin release in youths under both fasting and fed conditions.