Ambrosy AP, Yang J, Sung SH, et al. - In a contemporary cohort taking statin treatment, greater risk of atherosclerotic cardiovascular disease events and lower risk of death were evident in relation to elevated triglyceride levels.

• This is a retrospective analysis of adults aged ≥45 years taking statins, with a low‐density lipoprotein cholesterol of 41 to 100 mg/dL, and ≥1 risk factor or established atherosclerotic cardiovascular disease.

• A total of 373,389 primary prevention patients and 97,832 secondary prevention patients were analyzed.

• Multivariable analyses demonstrated a lower adjusted risk of death (hazard ratio [HR], 0.91) and higher risk of major adverse cardiovascular events (HR, 1.14) in primary prevention patients with triglyceride levels ≥150 mg/dL.In the secondary prevention cohort, there was a lower adjusted risk of death (HR, 0.95) and higher risk of all‐cause hospitalization (HR, 1.03) and major adverse cardiovascular events (HR, 1.04) in patients having triglyceride levels ≥150 mg/dL.