Gupta V, et al. - Trends in resistance for Enterobacteriaceae and Acinetobacter spp. from 2013 to 2017 in hospitalized US patients were investigated given their utility in informing infection control efforts. Antimicrobial susceptibility of non-duplicate isolates was assessed in hospitalized patients (not limited to hospital-acquired infections) in the US BD Insights Research Database. From 411 hospitals, researchers obtained more than 1 million Enterobacteriaceae isolates; 12.05% were extended-spectrum beta-lactamase (ESBL), 1.21% carbapenem-nonsusceptible (Carb-NS), and 7.08% multidrug-resistant (MDR). Between 2013 and 2017, an increase in the rates of ESBL and Carb-NS Enterobacteriaceae per 100 hospital admissions was observed in this large-scale study of patients in US hospitals. Over this period, they observed a decrease in MDR Enterobacteriaceae and MDR and Carb-NS Acinetobacter spp. isolates. This study thereby supports maintaining infection control and stewardship efforts and the development of new therapeutic options.