Chang SH, Patel N, Du M, et al. - Researchers here analyzed incidence trends of colorectal cancer (CRC) utilizing high-quality data from 92% of the US population, with a focus on those younger than 50 years. The United States Cancer Statistics database (2001-2016) was used. They analyzed 191,659 cases of early-onset and 1,097,765 cases of late-onset CRC over the study span. A rise in CRC incidence was evident in every age group from 20 to 54 years. A consistent elevation in incidence across all younger ages was evident only among Whites, with the steepest increase observed after 2012. Also, smaller increases in incidence were shown by Hispanics in most of the younger age groups. For males, left-sided tumors, and regional and distant disease, there was a greater rise in early-onset CRC incidence. Findings demonstrated an overall increase in the incidence of early-onset CRC from 2001 to 2016, however, the observed trends were markedly different for Whites, Blacks, Asians/Pacific Islanders, and Hispanics.