Stoeter O, Seraphin TP, Chitsike I, et al. - Researchers utilized data from two population‐based cancer registries in Harare (Zimbabwe) and Kyadondo (Uganda), to analyze trends in childhood cancer incidence in sub‐Saharan Africa, as well as to identify causes for noted variations and changes. Cases were classified as per the International Classification of Childhood Cancer. Only small, and non‐significant overall trends in incidence were revealed during the whole 25‐year period (1991‐2015) studied. Within the period, there were peaks in incidence from 1996‐2001 in Harare (Zimbabwe) and from 2003‐2006 in Kyadondo (Uganda). During these periods, most of the cases were attributable to Kaposi sarcoma and non‐Hodgkin lymphoma. The findings demonstrate that registration of childhood cancer cases in resource‐poor settings was associated with the availability of diagnostic services mediated by economic developments. Overall, specialised diagnostic and treatment programs for childhood cancer patients are required, and HIV programs confer positive impacts on certain childhood malignancies.