Del Grande C, Schiavi E, Masci I, et al. - A cohort of 101 Italian inpatients affected by mood or schizophrenia-spectrum disorders was investigated for the seroprevalence of Toxoplasma gondii. Further, clinical features between seronegative and seropositive individuals were compared. IgG anti–T. gondii were detected in 28 patients (27.7%), and there was no individual with IgM antibodies. Patients aged 40 years or older had higher prevalence rate, as compared with younger. Although there was no significant correlation between T. gondii and a specific diagnostic category; bipolar disorder (BD)-II exhibited the highest positivity rate (40.9%). Findings suggested a significant correlation of the seropositive status with a lower presence of psychotic symptoms, higher number of total episodes of predominant excitatory polarity, longer illness duration, and lower severity of current episode, especially anxiety, depressive, and withdrawal/retardation symptoms. These preliminary results seemed to provide support to an association between chronic toxoplasmosis and a specific subtype of BD.