van Boven N, et al. - In a study population comprising chronic heart failure (CHF) patients, researchers assessed the prognostic information of detailed temporal patterns of N-terminal proBNP (NT-proBNP), high-sensitive troponin T (HsTNT) and C-reactive protein (CRP). Findings demonstrated that in an independent manner, temporal patterns representing evolution of level and rate of change in level of NT-proBNP and CRP, and long-term elevation of NT-proBNP were related to adverse prognosis. The potential utility of individual patterns of change and combining multiple biomarkers was suggested for prognostication and for therapy guidance.