Omoto S, Kitano M, Fukasawa M, et al. - For distinguishing pancreatic carcinoma from other pancreatic tumors, researchers evaluated the accuracy of tissue harmonic endoscopic ultrasonography (TH‐EUS) vs contrast‐enhanced harmonic endoscopic ultrasonography (CH‐EUS) via this prospective multicenter study of consecutive patients with solid pancreatic tumor. Four parameters of TH‐EUS (fuzzy edge, irregular periphery, hypoechogenicity, and heterogeneous internal echogenicity) and four parameters of CH‐EUS (hypoenhancement and heterogeneous enhancement in early and late phases, respectively) were compared to determine the most suitable parameter of each method for making diagnosis of pancreatic carcinomas. Enrollment of a total of 204 patients was done. Among TH‐EUS findings, the most accurate diagnostic parameter was irregular periphery for differentiating pancreatic carcinomas, with sensitivity, specificity, and accuracy of 95.0%, 42.9%, and 77.5%, respectively. Among CH‐EUS findings for differentiating pancreatic carcinomas, they identified late phase hypoenhancement to be the most accurate diagnostic parameter, with sensitivity, specificity, and accuracy of 90.8%, 74.6%, and 84.8%, respectively. For diagnosis of pancreatic carcinoma, CH‐EUS (late phase hypoenhancement) was significantly more accurate than TH‐EUS (irregular periphery).