Kaalby L, et al. - Through a cross-sectional study design with all 62,554 patients registered in the Danish Colorectal Cancer Screening Database who tested FIT-positive between March 2014 and December 2016, experts examined if response time from the Fecal Immunochemical Test (FIT) based screening invitation to the conclusive screening Optical Colonoscopy (OC) impacted the risk of detecting colorectal cancer (CRC), advanced-stage disease and precursor lesions. A total of 53,171/62,554 received an OC and were eligible for review. Collectively, 3,639 cancers were registered, 2,890 and 1,042 of which were registered with a defined stage of the disease and advanced stage (UICC III & IV), respectively. There were 17,732 and 10,605 high-risk and low-risk adenomas, respectively, were recognized as well. Those examined more than 90 days following the initial invitation had 3.49 higher odds of being diagnosed with any CRC and had 2.10 higher odds of being diagnosed with advanced-stage disease vs participants who were examined within 30 days. Having one or more high-risk adenomas was more likely among those waiting the longest. Increased screening response time had a correlation with higher odds of identifying high-risk adenomas, any stage CRC and advanced-stage cancer.