According to findings, both of nocturnal trough systolic blood pressure (NTSBP) and Time Point of Nocturnal Trough Systolic Blood Pressure (T-NTSBP) were crucial predictors for short-term cardiovascular risk in ischemic stroke and transient ischemic attack (TIA) patients.

• Data from a nationwide ambulatory blood pressure monitoring cohort study, which recruited 2,348 ischemic stroke and TIA patients, were utilized to assess the link between NTSBP/T-NTSBP and stroke outcome.

• NTSBP was described as the lowest SBP during nighttime (22:00–6:00), and T-NTSBP was defined as the corresponding time point of NTSBP.

• By NTSBP classified by quartile, hazard ratio (HR) with 95% confidence interval (CI) for NTSBP quartile 4 (>129 mm Hg) was estimated to be 2.727 (1.148–6.478) for combined vascular event [CVE] at 90-day, vs quartile 1 (≤102 mm Hg).

• At 1 year, there was an attenuated link between NTSBP and CVE.

• A lowest CVE incidence at 90 days was present in the group of T-NTSBP at 4:00–6:00 among the four groups (22:00–23:59, 00:00–1:59 2:00–3:59, 4:00–6:00).

• Post-multivariable adjustment, a significant association of T-NTSBP with CVE incidence at 90 days was found (T-NTSBP at the 4:00–6:00 vs the 22:00–23:59 group: HR, 0.433), independent of NTSBP and average nocturnal SBP.