Vendrami C, Marques-Vidal P, Gonzalez Rodriguez E, et al. - The findings of this study revealed that thyroid-stimulating hormone (TSH) levels were positively correlated with TBS and negatively with incident fractures, without affecting bone mineral density (BMD) in euthyroid postmenopausal women. There is a need for further studies to investigate the influence of thyroid hormones on the trabecular bone score (TBS).

• Researchers recruited a total of 533 women (age 68.4 ± 7.3 years, BMI 25.9 ± 4.6 kg/m2, TSH 2.03 ± 0.87 mU/l, fT4 15.51 ± 1.85 pmol/l).

• No significant relationship was found between TSH or fT4 and BMD measures at any site.

• There was a positive relationship between TSH and TBS (β = 0.138, p < 0.01), even after adjusting for age, BMI, and duration of menopause (β = 0.086, p < 0.05).

• It has been reported that women with incident major OP fractures had lower TSH levels (1.77 ± 0.13 vs. 2.05 ± 0.04 mU/l, p < 0.05) than women without fractures after a 5-year follow-up, while no difference was found for fT4.