Seo SM, et al. – In this study, researchers investigated whether hypothyroidism is associated with higher mortality in patients with acute myocardial infarction (AMI). Of the 4,748 patients with AMA undergoing percutaneous coronary intervention (PCI) with drug-eluting stents who were consecutively enrolled in the study, 1,977 AMI were included in the final analysis. The all-cause and cardiac mortalities were compared between the euthyroid group (n=1,846) with normal thyroid-stimulation hormone (TSH) and normal free thyroxine (FT4) levels and the hypothyroidism group (n=131) with elevated TSH and normal or low FT4 levels. Findings revealed worse clinical outcome in AMI patients with TSH elevation. Moreover, TSH elevation was identified as a predictor of all-cause mortality in patients with AMI.