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Thyroid nodules in childhood‐onset Hashimoto’s thyroiditis: Frequency, risk factors, follow‐up course, and genetic alterations of thyroid cancer

Clinical Endocrinology Apr 28, 2021

Lee YJ, Cho YJ, Heo YJ, et al. - Researchers conducted this retrospective cohort study to assess the frequency, risk factors, and the follow‐up outcomes of thyroid nodules, and genetic alterations in thyroid cancer, in youth with childhood‐onset Hashimoto thyroiditis (HT) who lived in an iodine‐sufficient country. In total, 213 patients (194 females, mean age 10.6 years at the time of HT diagnosis) were ultrasonographically assessed. Using the Korean Thyroid Imaging Reporting and Data System (K‐TIRADS) and the American College of Radiology Thyroid Imaging Reporting and Data System (ACR‐TI‐RADS), thyroid nodules were categorized. In childhood-onset HT patients, the nodule detection rate was 18.8%, with a 22.5% risk of malignancy among the observed nodules, indicating an elevated risk among those with a family history. Additional large‐scale studies are needed to assess the utility of K‐TIRADS or ACR‐TI‐RADS risk level for the differentiation of pediatric thyroid nodules.

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