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Thyroid function and the risk of prediabetes and type 2 diabetes

Journal of Clinical Endocrinology and Metabolism Feb 12, 2022

As per current evidence, individuals with hypothyroidism and lower free thyroxine (FT4) levels in the reference range have an elevated risk of type 2 diabetes. There is a need for further population-based studies to address this association given the limited evidence.

  • From Embase, Medline (Ovid), Web of Science, Cochrane, and Google Scholar, prospective studies examining the link of thyroid function and incident type 2 diabetes were identified.

  • Researchers found 4574 publications of which 7 met the inclusion criteria and were included in the qualitative synthesis and six publications were analyzed in the meta-analysis.

  • Pooled hazard ratios for the risk of type 2 diabetes were 1.26, 1.16, 1.06, and 0.95 for hypothyroidism, hyperthyroidism, thyrotropin in the reference range, and for FT4 in the reference range, respectively.

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