Creeth J, Maclure R, Seong J, et al. - In this investigation, researchers assessed the impacts on dentine hypersensitivity (DH; defined as ‘pain derived from exposed dentine in response to chemical, thermal, tactile or osmotic stimuli’) applied by the fingertip of a 0.454% stannous fluoride (SnF₂) sample toothpaste, then 3 days of brushing, compared with a sodium monofluorophosphate-based control. DH was evaluated utilizing evaporative (Schiff scale) and tactile (Yeaple probe) stimuli in three randomized clinical studies. Findings suggested that 0.454% of SnF₂ formulated as an anhydrous, polyphosphate-containing base can decrease DH pain once applied directly to hypersensitive teeth by fingertip, compared with conventional fluoride toothpaste. DH relief increased twice-daily brushing for more than 3 days. In general, toothpastes were well-tolerated.