Chen Z, Jiang H, Wang Y, et al. - This investigation was carried out in a hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) population, to examine the link between postoperative antibiotics and hepatectomy-related infection. Researchers retrospectively obtained 934 HCC patients who had hepatectomy for curative intent from three tertiary hospitals in China. They documented and computed incidences of postoperative infection including surgical site infection and remote site infection. An overall infection rate of 8.2% (77/934) was noted, including 6.5% (61/934) of surgical site infection and 2.0% (19/934) of remote site infection. According to findings, it is necessary to administer postoperative antibiotics for avoiding the development of postoperative infection in HBV-related HCC patients, particularly in those who exhibit higher albumin-bilirubin score, at Barcelona Clinic Liver Cancer stage B–C, or who had major hepatectomy. Postoperative second-generation cephalosporins, or ceftriaxone for 3 days post-surgery might be appropriate for HBV-related HCC patients.